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KMID : 0388420000100010059
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Konkuk Journal of Medical Sciences
2000 Volume.10 No. 1 p.59 ~ p.67
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Clinical Significance of CA125 in Ovarian Cancer
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Yun Byoung-Il
Kim Soo-Nyung
Sohn In-Sook
You Yeon-Wung
Choi Won-Suk
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Abstract
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The concentration of the tumor marker CAl25 in serum from patientsR with ovarian tumor was measured to define the usefulness of them in differentiating malignant ovarian tumor from benign ovarian mass. In the study of 105 patients with gynecologic neoplasm, of whom 38 were myoma uteri, 42 benign ovarian tumor, and 25 ovarian cancer, the level of serum CAl25 were measured. CAl25 was greater than 35 U/ml in 2.6% of myoma uteri, in 2.491% of benign ovarian tumors and 68.0% of ovarian cancers.
Using a cut-off level of 35 U/ml, the results can be characterized by a 68.0% ofd sensitivity and 97.5% of specificity in detecting an ovarian cancer. Among 25, patients with ovarian cancer, 11 of 14 (78.6%) patients with serous cystadenocarcinoma, 4 of 6 (66.7%) patients with mucinous cystadenocarcinoma and 2 of 5 (40.0%) patients with endometrioid carcinoma had CAl25 values greater than 35 U/ml.
In relation to a higher tumor stage, there was an increasing incidence of elevated levels of CAl25.
As a result, it is likely that the measurement of CAl25 is useful for early diagnosis of ovarian cancer.
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KEYWORD
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CA125, ovarian cancer
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